Radiobiological Assessment of IMRT Treatment Plans

Radiobiological impact of dose calculation algorithms on biologically optimized IMRT lung stereotactic body radiation therapy plans

BACKGROUND The aim of this study is to evaluate the radiobiological impact of Acuros XB (AXB) vs. Anisotropic Analytic Algorithm (AAA) dose calculation algorithms in combined dose-volume and biological optimized IMRT plans of SBRT treatments for non-small-cell lung cancer (NSCLC) patients. METHODS Twenty eight patients with NSCLC previously treated SBRT were re-planned using Varian Eclipse (V...

Dosimetric and radiobiological comparison for quality assurance of IMRT and VMAT plans

INTRODUCTION The gamma analysis used for quality assurance of a complex radiotherapy plan examines the dosimetric equivalence between planned and measured dose distributions within some tolerance. This study explores whether the dosimetric difference is correlated with any radiobiological difference between delivered and planned dose. METHODS VMAT or IMRT plans optimized for 14 cancer patient...

Evaluation of complexity and deliverability of IMRT - treatment plans

IMRT optimization: variability of solutions and its radiobiological impact.

We aim at (1) defining and measuring a "complexity" index for the optimization process of an intensity modulated radiation therapy treatment plan (IMRT TP), (2) devising an efficient approximate optimization strategy, and (3) evaluating the impact of the complexity of the optimization process on the radiobiological quality of the treatment. In this work, for a prostate therapy case, the IMRT TP...

Evaluation of the radiobiological gamma index with motion interplay in tangential IMRT breast treatment

The purpose of this study was to evaluate the impact of the motion interplay effect in early-stage left-sided breast cancer intensity-modulated radiation therapy (IMRT), incorporating the radiobiological gamma index (RGI). The IMRT dosimetry for various breathing amplitudes and cycles was investigated in 10 patients. The predicted dose was calculated using the convolution of segmented measured ...